What is Ustekinumab?

Ustekinumab is a targeted disease modifying anti-rheumatic drug (DMARD) that is used to reduce inflammation produced by the body. In certain diseases the immune system is over active, this can target healthy tissues such as joints and the skin. Ustekinumab works on the inflammatory pathway to block inflammation, thereby reducing the symptoms you get from arthritis such as pain and joint swelling and reduces the chance of further damage to the joints.


What is Ustekinumab used for?

Ustekinumab is used for the treatments of psoriasis and psoriatic arthritis.


How is it taken?

Ustekinumab is given as an injection into the layer of fat between the skin and muscle. This is called a subcutaneous injection and is usually given into the thigh or abdomen. It can be given alone or in combination with other DMARDs such as methotrexate.

The injection device is available as a prefilled syringe. It should be stored in the fridge at home.


The injections are given initially as loading doses of 45mg or 90mg (depending on your weight) at weeks 0 and 4. You will then take the injection every 12 weeks thereafter.


It can take up to 24 weeks (6 months) to have a full effect. You will be seen in clinic at around 3-4 months to see how you are getting along.


Whilst you are taking ustekinumab you will need your bloods monitored. This is done every 3 months. If you are taking other DMARDs that require blood monitoring then you should continue these.


Side effects

There are a few possible side effects that can occur in a small number of people that take ustekinumab, these include:



Cautions of use

Interactions with other medications

Contraindications of other conditions


During pregnancy and breastfeeding




Useful Links

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